Zidovudine (Retrovir) is an antiviral prescription drug, which is used for the treatment of HIV infection in adults and children 4 weeks of age and older. Zidovudine is a nucleoside reverse transcriptase inhibitor that decreases the amount of HIV in the body so that the body"s immune system could work better. Zidovudine is not a cure for HIV infection, but it slows down the damage to the body"s immune system.
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Zidovudine belongs to the drug class of NRTIs (Nucleoside reverse transcriptase inhibitors). NRTIs have the ability to inhibit reverse transcriptase enzyme that is found in human immunodeficiency viruses or retroviruses. Zidovudine, thus works by inhibiting the reproduction of the HIV virus in the blood. It, therefore, minimizes the chance of getting HIV-related complications such as cancer or other infections, if any. Zidovudine is also taken with other drugs to prevent women from transferring HIV virus to the unborn baby during pregnancy. Zidovudine comes in the form of oral capsules, which should be taken exactly as prescribed by your doctor. Below you will find the uses of Zidovudine.
The dosage of Zidovudine will depend on the strength of each pill and the frequency with which it is being taken. The drug dose may be altered by the doctor depending on the medical condition of the patient. You should always take medication precisely as your doctor prescribes it to you. Below you will find a typical dosage of Zidovudine.
- Adults: 300 mg orally every 12 hours or 200 mg orally every 8 hours
Pediatric dose of Zidovudine for 4 weeks and less than 18 years old
- 4 to < 9 kg: 12 mg/kg orally twice a day or 8 mg/kg orally 3 times a day
- 9 to < 30 kg: 9 mg/kg orally twice a day or 6 mg/kg orally 3 times a day
- 30 kg or more: 300 mg orally twice a day or 200 mg orally 3 times a day
Zidovudine Side Effects
Like any drug, Zidovudine may cause side effects. However, the symptoms may vary from one individual to another who uses it. If you experience severe or persistent side effects, stop taking the medicine and immediately inform your doctor for medical attention. Besides, you must tell your doctor if you are allergic to Zidovudine. Below you will find a list of side effects associated with Zidovudine. Contact your doctor if you experience any of the following symptoms. Note that not all possible side effects are listed.
- Shortness of breath
- Unusual breathing
- Weakness or tiredness
- Sore throat
- Upset stomach
- Muscle weakness
Like any drug, Zidovudine may interact with other drugs and substances. Drug interactions may cause an increased risk of side effects or change the way your medication works. Consult your doctor before taking any medication, including over the counter drugs and supplements. Below you will find a list of drugs that may interact with Zidovudine. Note that not all possible interactions are listed here.