Nucleoside Metabolic Inhibitors are considered to slow down the growth of cancer cells. Within the inhibitors, is the deoxynucleoside analogs like the 5-aza-2-deoxycytidine, referred to as Z, are turned into triphosphate while within the S-phase cells. They are then absorbed in place of the cytosine into DNA. Ribonucleosides like the zebularine and 5-azacytidine are minimized at the diphosphate level by the ribonucleotide reductase and are applied in the incorporation process. When in DNA, the false base from the covalent bonds with DNA methyltransferases, leading to the reduction of active enzymes and demethylation process of DNA.
Nucleoside Metabolic Inhibitors Drugs
Below you will find a list of drugs that fall under the class of Nucleoside Metabolic Inhibitors.
Nucleoside Metabolic Inhibitors Uses
Nucleoside metabolic inhibitors are most useful in the treatment of breast cancer, colon cancer, leukemia, actinic keratosis, meningitis, pancreatic cancer, skin cancer, lung cancer and ovarian cancer.
The inhibitor works by slowing down the development of cancer cells and by this kills the cells.
Nucleoside Metabolic Inhibitors Side Effects
All medications used to treat malignancy reason side effects. Side effects are undesirable things that can befall you as an immediate consequence of medicinal treatment _ for this situation, taking a growth treatment drug. It can now and then be not difficult to befuddle medication side effects with manifestations of the tumor. Manifestations are the things that befall you as an immediate consequence of the disease and are not because of your treatment. Treatment may contract your growth and bring about a significant improvement.
Some of the side effects of these inhibitors include:
- Hair loss
- Hair thinning
Nucleoside Metabolic Inhibitors Interactions
Before using Nucleoside Metabolic Inhibitors, inform your doctor or pharmacist in case you are allergic to it, or to other cancer treatment drugs; or if you have any additional allergies. This medication might have inactive ingredients, which can lead to allergic reactions or other related problems.
Additionally, inform your pharmacist or doctor of your entire medical history, particularly of: cells and blood disorders.
Avoid the use of alcohol while using this drug and for as minimum as one day after finishing the medication. This is majorly because consuming alcohol might lead to nausea, chronic stomach cramps, headache, flushing, and vomiting.